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1

Studies on the metabolic fate of carvedilol. (V). Transfer into the fetuses in rats.

HAKUSUI, Hideo, FUJIMAKI, Masayoshi, ESUMI, Yoshio, TAKAICHI, Matsuo, SEKI, Hideaki, MATSUURA, Chizuko

Journal:

Drug Metabolism and Pharmacokinetics

Year:

1989

File:

PDF, 5.82 MB

1989

2

Metabolism of Methylscopolammonium Methylsulfate (DD-234) in Rats

SANO, MITSUJI, HAKUSUI, HIDEO

Journal:

CHEMICAL & PHARMACEUTICAL BULLETIN

Year:

1974

File:

PDF, 1.05 MB

1974

3

Quantitative analysis of oxepinac in human plasma, urine and saliva by gas chromatography—mass fragmentography

Hideo Hakusui, Wataru Suzuki, Mitsuji Sano

Journal:

Journal of Chromatography B: Biomedical Sciences and Applications

Year:

1980

Language:

english

File:

PDF, 455 KB

english, 1980

4

Mass fragmentographic determination of lofepramine and its metabolites in human plasma and urine using deuterated internal standards

Kyuichi Matsubayashi, Hideo Hakusui, Mitsuji Sano

Journal:

Journal of Chromatography B: Biomedical Sciences and Applications

Year:

1977

Language:

english

File:

PDF, 821 KB

english, 1977

5

Quantitative analysis of budralazine in human plasma and urine by gas chromatography-mass spectrometry

Yuko Fujimaki, Hideo Hakusui, Toshio Takegoshi

Journal:

Journal of Chromatography B: Biomedical Sciences and Applications

Year:

1987

Language:

english

File:

PDF, 282 KB

english, 1987

6

Metabolism of Irinotecan to SN-38 in a Tissue-Isolated Tumor Model.

ATSUMI, Ryo, OKAZAKI, Osamu, HAKUSUI, Hideo

Journal:

Biological & Pharmaceutical Bulletin

Year:

1995

File:

PDF, 490 KB

1995

7

Toxicokinetics: Its significance and practical problems.

KATO, Ryuichi, CASE, David E., HAKUSUI, Hideo, NODA, Kosei, SAGAMI, Fumio, HORII, Ikuo, MAYAHARA, Hiroshi, CAYEN, Mitchell N., MARRIOTT, Thomas B., IGARASHI, Toshiji

Journal:

The Journal of Toxicological Sciences

Year:

1993

File:

PDF, 2.71 MB

1993

8

Studies on the metabolic fate of carvedilol. (I). Pharmacokinetics in rat following a single oral dose.

HAKUSUI, Hideo, FUJIMAKI, Masayoshi, ESUMI, Yoshio, TAKAICHI, Matsuo, SAITOU, Takako, OOTSUKI, Miyuki, MIYAKE, Takayuki, HONDA, Naoko

Journal:

Drug Metabolism and Pharmacokinetics

Year:

1989

File:

PDF, 6.37 MB

1989

9

The Pharmacokinetics of DR-3355. (IV): Absorption, Distribution and Excretion after a Single Oral Administration to Monkeys.

KURATA, Tadashi, AOKI, Hiroyuki, OKAZAKI, Osamu, HAKUSUI, Hideo, Esumi, Yoshio, MITSUGI, Koichi, KATAMI, Yoshiharu, WATANABE, Isao, OHBU, Yuko, OKADA, Minori

Journal:

Drug Metabolism and Pharmacokinetics

Year:

1991

File:

PDF, 4.68 MB

1991

10

Pharmacokinetics of midaglizole, a new hypoglycaemic agent, in healthy subjects

Hisashi Nomura, Fusako Yamada, Hideo Hakusui

Journal:

Biopharmaceutics & Drug Disposition

Year:

1990

Language:

english

File:

PDF, 586 KB

english, 1990

11

Assay and disposition of carvedilol enantiomers in humans and monkeys: Evidence of stereoselective presystemic metabolism

Masayoshi Fujimaki, Yukiko Murakoshi, Hideo Hakusui

Journal:

Journal of Pharmaceutical Sciences

Year:

1990

Language:

english

File:

PDF, 529 KB

english, 1990

12

Simple isocratic high-performance liquid chromatographic method for measurement of iodixanol in human plasma

Hisashi Nomura, Emiko Teshima, Hideo Hakusui

Journal:

Journal of Chromatography B: Biomedical Sciences and Applications

Year:

1991

Language:

english

File:

PDF, 406 KB

english, 1991

13

A Pharmacokinetic and Pharmacodynamic Analysis of CPT-11 and Its Active Metabolite SN-38

Yasutsuna Sasaki, Hideo Hakusui, Shoichi Mizuno, Masashige Morita, Toshimichi Miya, Kenji Eguchi, Tetsu Shinkai, Tomohide Tamura, Yuichiro Ohe, Nagahiro Saijo

Journal:

Year:

1995

File:

PDF, 567 KB

1995

14

Studies on the Pharmacokinetics of Ebselen in Rats (1): Absorption, Distribution, Metabolism and Excretion after Single Oral Administration.

MASUMOTO, Hiroshi, HASHIMOTO, Kouichi, HAKUSUI, Hideo, TAKAICHI, Matsuo, YOKOTA, Takashi, HONDA, Takako, ESUMI, Yoshio

Journal:

Drug Metabolism and Pharmacokinetics

Year:

1997

File:

PDF, 9.00 MB

1997

15

Studies on the metabolic fate of carvedilol. (IV). Transfer into the milk in rats.

FUJIMAKI, Masayoshi, SHINTANI, Shouzou, HAKUSUI, Hideo

Journal:

Drug Metabolism and Pharmacokinetics

Year:

1989

File:

PDF, 1.94 MB

1989

16

Pharmacological Correlation between Total Drug Concentration and Lactones of CPT-11 and SN-38 in Patients Treated with CPT-11

Yasutsuna Sasaki, Yasushi Yoshida, Kenichi Sudoh, Hideo Hakusui, Hirofumi Fujii, Tomoko Ohtsu, Hisashi Wakita, Tadahiko Igarashi, Kuniaki Itoh

Journal:

Year:

1995

File:

PDF, 348 KB

1995

17

Metabolic Activation of CPT-11, 7-Ethyl-10-(4-(1-piperidino)-1-piperidino)carbonyloxycamptothecin, a Novel Antitumor Agent, by Carboxylesterase.

SATOH, Tetsuo, HOSOKAWA, Masakiyo, ATSUMI, Ryo, SUZUKI, Wataru, HAKUSUI, Hideo, NAGAI, Eiichi

Journal:

Biological & Pharmaceutical Bulletin

Year:

1994

File:

PDF, 527 KB

1994

18

Phase I Study of Levofloxacin, (S)-(-)-Ofloxacin.

NAKASHIMA, Mitsuyoshi, UEMATSU, Toshihiko, KANAMARU, Mitsutaka, OKAZAKI, Osamu, HAKUSUI, Hideo

Journal:

Rinsho yakuri/Japanese Journal of Clinical Pharmacology and Therapeutics

Year:

1992

Language:

english

File:

PDF, 730 KB

english, 1992

19

Inhibitory Activity of Camptothecin Derivatives Against Acetylcholinesterase in Dogs and Their Binding Activity to Acetylcholine Receptors in Rats

KAWATO, YASUYOSHI, SEKIGUCHI, MASAYASU, AKAHANE, KOUICHI, TSUTOMI, YUMI, HIROTA, YASUHIDE, KUGA, HIROSHI, SUZUKI, WATARU, HAKUSUI, HIDEO, SATO, REIKI

Journal:

Journal of Pharmacy and Pharmacology

Year:

1993

Language:

english

File:

PDF, 470 KB

english, 1993

20

Studies on the metabolic fate of carvedilol. (III). Biliary excretion and enterohepatic circulation in rats.

FUJIMAKI, Masayoshi, HAKUSUI, Hideo

Journal:

Drug Metabolism and Pharmacokinetics

Year:

1989

File:

PDF, 1.89 MB

1989

21

The Pharmacokinetics of DR-3355. (II): Absorption, Distribution and Excretion after Repeated Oral Administration to Rats.

AOKI, Hiroyuki, OKAZAKI, Osamu, HAKUSUI, Hideo, Esumi, Yoshio, MITSUGI, Koichi, KATAMI, Yoshiharu, WATANABE, Isao, OHBU, Yuko, OKADA, Minori

Journal:

Drug Metabolism and Pharmacokinetics

Year:

1991

File:

PDF, 5.27 MB

1991

22

Effects of proton pump inhibitors on thyroid hormone metabolism in rats: A comparison of UDP-glucuronyltransferase induction

Noriko Masubuchi, Hideo Hakusui, Osamu Okazaki

Journal:

Biochemical Pharmacology

Year:

1997

Language:

english

File:

PDF, 793 KB

english, 1997

23

The Pharmacokinetics of DR-3355. (III): Absorption and Excretion after a Single Oral Administration to Dogs.

AOKI, Hiroyuki, OKAZAKI, Osamu, HAKUSUI, Hideo, Esumi, Yoshio, MITSUGI, Koichi, KATAMI, Yoshiharu, WATANABE, Isao, OHBU, Yuko, OKADA, Minori

Journal:

Drug Metabolism and Pharmacokinetics

Year:

1991

File:

PDF, 2.34 MB

1991

24

Simple and selective assay of 4-hydroxymephenytoin in human urine using solid-phase extraction and high-performance liquid chromatography with electrochemical detection and its preliminary application to phenotyping test

Makoto Tanaka, Kinuyo Kato, Ken-ichi Sudo, Hideo Hakusui, Tadashi Ohkubo, Kazunobu Sugawara, Sunao Kaneko, Koichi Otani, Kan Chiba, Takashi Ishizaki

Journal:

Journal of Chromatography B: Biomedical Sciences and Applications

Year:

1996

Language:

english

File:

PDF, 509 KB

english, 1996

25

The Pharmacokinetics of DR-3355. (I): Absorption, Distribution and Excretion after a Single Oral Administration to Rats.

AOKI, Hiroyuki, OKAZAKI, Osamu, KURATA, Tadashi, SHINTANI, Shozo, TACHIZAWA, Haruo, HAKUSUI, Hideo

Journal:

Drug Metabolism and Pharmacokinetics

Year:

1991

File:

PDF, 5.82 MB

1991

26

Radioimmunoassay for DS-4574, an antiallergic agent: Development, evaluation, and application to human plasma samples

Nobuyuki Murayama, Minoru Nakaoka, Hisashi Nomura, Hideo Hakusui

Journal:

Journal of Pharmaceutical Sciences

Year:

1994

Language:

english

File:

PDF, 434 KB

english, 1994

27

Thermal Dehydration of Nafagrel Hydrochloride Hydrate at Controlled Water Vapor Partial Pressures.

KITAOKA, Hiroaki, OHYA, Kazumi, HAKUSUI, Hideo

Journal:

CHEMICAL & PHARMACEUTICAL BULLETIN

Year:

1995

File:

PDF, 740 KB

1995

28

Synthetic Studies on Anthracyclinones. X. : Synthesis of Methyl 2-(1-Acetoxy-3-oxobutyl) phenylacetate

HORII, ZENICHI, HAKUSUI, HIDEO, SHIGEUCHI, TOSHIAKI, HANAOKA, MIYOJI, MOMOSE, TAKEFUMI

Journal:

YAKUGAKU ZASSHI

Year:

1972

File:

PDF, 575 KB

1972

29

Resolution of enantiomers of a novel thromboxane synthetase inhibitor by HPLC on a chiral stationary phase.

TANAKA, Makoto, HAKUSUI, Hideo

Journal:

Year:

1995

File:

PDF, 627 KB

1995

30

Studies on the Pharmacokinetics of Ebselen in Rats (1): Absorption, Distribution, Metabolism and Excretion after Single Oral Administration.

MASUMOTO, Hiroshi, HASHIMOTO, Kouichi, HAKUSUI, Hideo, TAKAICHI, Matsuo, YOKOTA, Takashi, HONDA, Takako, ESUMI, Yoshio

Journal:

Drug Metabolism and Pharmacokinetics

Year:

1997

Language:

english

File:

PDF, 9.00 MB

english, 1997

31

Chemical Characterization of a Sulfated Polysaccharide–Peptidoglycan Complex from an Arthrobacter sp.

Yamazaki, Ken-ichi, Suzuki, Makoto, Inukai, Kazuyoshi, Hakusui, Hideo

Journal:

Bioscience Biotechnology and Biochemistry

Year:

1997

Language:

english

File:

PDF, 552 KB

english, 1997

32

Determination of a new fluoroquinolone antimicrobial agent, (S)-10-[(S)-(8-amino-6-azaspiro[3,4]octan-6-yl]-9-fluoro-2,3-dihydro-3-methyl-7-oxo-7H-pyrido[1,2,3-de[1,4] benzoxazine-6-carboxylic acid hemihydrate, DV-7751a, in human serum and urine using solid-phase extraction and high-performance liquid chromatography with fluorescence detection

Makoto Tanaka, Yumi Oshima, Hiroyuki Aoki, Hideo Hakusui

Journal:

Journal of Chromatography B: Biomedical Sciences and Applications

Year:

1995

Language:

english

File:

PDF, 403 KB

english, 1995

33

Metabolic disposition of pantoprazole, a proton pump inhibitor, in relation to S-mephenytoin 4′-hydroxylation phenotype and genotype*

Tanaka, Makoto, Ohkubo, Tadashi, Otani, Koichi, Suzuki, Akihito, Kaneko, Sunao, Sugawara, Kazunobu, Ryokawa, Yuichi, Hakusui, Hideo, Yamamori, Shunji, Ishizaki, Takashi

Journal:

Clinical Pharmacology & Therapeutics

Year:

1997

Language:

english

File:

PDF, 960 KB

english, 1997

34

Simultaneous determination of nefiracetam and its metabolites by high-performance liquid chromatography

Yuko Fujimaki, Kenichi Sudo, Hideo Hakusui

Journal:

Journal of Chromatography B: Biomedical Sciences and Applications

Year:

1992

Language:

english

File:

PDF, 579 KB

english, 1992

35

Synthesis of Bisanhydroaklavinone

Horii, Zen-ichi, Hakusui, Hideo, Momose, Takefumi

Journal:

CHEMICAL & PHARMACEUTICAL BULLETIN

Year:

1966

File:

PDF, 437 KB

1966

36

High-performance liquid chromatographic determination of the new quinolone antibacterial agent DU-6859a in human serum and urine using solid-phase extraction with photolysis—fluorescence detection

Hiroyuki Aoki, Yumi Ohshima, Makoto Tanaka, Osamu Okazaki, Hideo Hakusui

Journal:

Journal of Chromatography B: Biomedical Sciences and Applications

Year:

1994

Language:

english

File:

PDF, 747 KB

english, 1994

37

High-performance liquid chromatographic determination of (S)-(−)-ofloxacin and its metabolites in serum and urine using a solid-phase clean-up

Osamu Okazaki, Hiroyuki Aoki, Hideo Hakusui

Journal:

Journal of Chromatography B: Biomedical Sciences and Applications

Year:

1991

Language:

english

File:

PDF, 616 KB

english, 1991

38

Interaction of Quinolones with Metal Cations in Aqueous Solution.

KAWAI, Yukinori, MATSUBAYASHI, Kyuichi, HAKUSUI, Hideo

Journal:

CHEMICAL & PHARMACEUTICAL BULLETIN

Year:

1996

File:

PDF, 895 KB

1996

39

Modulation of Subcellular Particles of the Rat Small Intestine and Liver by Ebselen.

MIZOGUCHI, Tadashi, NISHINAKA, Tohru, NANJO, Hirofumi, YAGI, Kiyohito, HAKUSUI, Hideo

Journal:

Biological & Pharmaceutical Bulletin

Year:

1995

File:

PDF, 799 KB

1995

40

Synthetic Studies on Anthracyclinones. VI. The Friedel-Crafts Condensation between 3-Methoxyphthalic Anhydride and α-Naphthol Derivatives

HORII, ZENICHI, HAKUSUI, HIDEO, MOMOSE, TAKEFUMI, YOSHINO, ETSUKO

Journal:

CHEMICAL & PHARMACEUTICAL BULLETIN

Year:

1968

File:

PDF, 1.25 MB

1968

41

Measurement of the formation of a thioglucuronide, a metabolite of malotilate, in rat hepatic microsomes by high-performance liquid chromatography

Minoru Nakaoka, Hideo Hakusui

Journal:

Journal of Chromatography B: Biomedical Sciences and Applications

Year:

1990

Language:

english

File:

PDF, 332 KB

english, 1990

42

Identification of the metabolites of a new hypoglycaemic agent, midaglizole, in dogs

Nakaoka, Minoru, Hakusui, Hideo

Journal:

Year:

1987

Language:

english

File:

PDF, 784 KB

english, 1987

43

Absorption and Excretion of Tranexamic Acid following Intravenous, Intramuscular and Oral Administrations in Healthy Volunteers

SANO, Mitsuji, HAKUSUI, Hideo, KOJIMA, Chieko, AKIMOTO, Takeshi

Journal:

Rinsho yakuri/Japanese Journal of Clinical Pharmacology and Therapeutics

Year:

1976

File:

PDF, 2.75 MB

1976

44

Studies on the metabolic fate of carvedilol. (I). Pharmacokinetics in rat following a single oral dose.

HAKUSUI, Hideo, FUJIMAKI, Masayoshi, ESUMI, Yoshio, TAKAICHI, Matsuo, SAITOU, Takako, OOTSUKI, Miyuki, MIYAKE, Takayuki, HONDA, Naoko

Journal:

Drug Metabolism and Pharmacokinetics

Year:

1989

File:

PDF, 6.37 MB

1989

45

Isolation and characterization of a new thio-glucuronide, a biliary metabolite of malotilate in rats

Nakaoka, Minoru, Hakusui, Hideo, Takegoshi, Toshio

Journal:

Year:

1989

Language:

english

File:

PDF, 627 KB

english, 1989

46

Synthetic Studies on Anthracyclinones. VII. Synthesis of Bisanhydroaklavinone

HORII, ZENICHI, HAKUSUI, HIDEO, MOMOSE, TAKEFUMI

Journal:

CHEMICAL & PHARMACEUTICAL BULLETIN

Year:

1968

File:

PDF, 528 KB

1968

47

Studies on the metabolic fate of carvedilol. (IV). Transfer into the milk in rats.

FUJIMAKI, Masayoshi, SHINTANI, Shouzou, HAKUSUI, Hideo

Journal:

Drug Metabolism and Pharmacokinetics

Year:

1989

File:

PDF, 1.94 MB

1989

48

Pharmacokinetics of CPT-11 in rhesus monkeys

Makoto Inaba, Yasuyuki Ohnishi, Hajime Ishii, Yoshikuni Tanioka, Ysaushi Yoshida, Kenichi Sudoh, Hideo Hakusui, Naomi Mizuno, Kiyomi Ito, Yuichi Sugiyama

Journal:

Cancer Chemotherapy and Pharmacology

Year:

1997

Language:

english

File:

PDF, 178 KB

english, 1997

49

Quantitation of a new hypoglycaemic drug, 2-[2-(4,5-dihydro-1H-imidazol-2-yl)-1-phenylethyl] pyridine dihydrochloride sesquihydrate (DG-5128), in plasma by gas chromatography—mass spectrometry

Minoru Nakaoka, Atsuko Ohtani, Hideo Hakusui

Journal:

Journal of Chromatography B: Biomedical Sciences and Applications

Year:

1986

Language:

english

File:

PDF, 408 KB

english, 1986

50

Biotransformation of Chlormezanone, 2-(4-Chlorophenyl)-3-methyl-4-metathiazanone-1,1-dioxide, a Muscle-Relaxing and Tranquillizing Agent: the Effect of combination with Aspirin on its Metabolic Fate in Rats and Mice

Hakusui, Hideo, Tachizawa, Haruo, Sano, Mitsuji

Journal:

Year:

1978

Language:

english

File:

PDF, 662 KB

english, 1978

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